例如:"lncRNA", "apoptosis", "WRKY"

Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling.

EMBO J. 2012 Jun 13;31(12):2770-83. Epub 2012 May 01
Annika Meinander 1 , Christopher Runchel , Tencho Tenev , Li Chen , Chan-Hee Kim , Paulo S Ribeiro , Meike Broemer , Francois Leulier , Marketa Zvelebil , Neal Silverman , Pascal Meier
Annika Meinander 1 , Christopher Runchel , Tencho Tenev , Li Chen , Chan-Hee Kim , Paulo S Ribeiro , Meike Broemer , Francois Leulier , Marketa Zvelebil , Neal Silverman , Pascal Meier
+ et al

[No authors listed]

Author information
  • 1 The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, UK.

摘要


Caspases have been extensively studied as critical initiators and executioners of cell death pathways. However, caspases also take part in non-apoptotic signalling events such as the regulation of innate immunity and activation of nuclear factor-κB (NF-κB). How caspases are activated under these conditions and process a selective set of substrates to allow NF-κB signalling without killing the cell remains largely unknown. Here, we show that stimulation of the Drosophila pattern recognition protein PGRP-LCx induces DIAP2-dependent polyubiquitylation of the initiator caspase DREDD. Signal-dependent ubiquitylation of DREDD is required for full processing of IMD, NF-κB/Relish and expression of antimicrobial peptide genes in response to infection with Gram-negative bacteria. Our results identify a mechanism that positively controls NF-κB signalling via ubiquitin-mediated activation of DREDD. The direct involvement of ubiquitylation in caspase activation represents a novel mechanism for non-apoptotic caspase-mediated signalling.