An optimized two-finger archive for ZFN-mediated gene targeting.
Nat. Methods. 2012 Jun;9(6):588-90. Epub 2012 Apr 29
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摘要
The widespread use of zinc-finger nucleases (ZFNs) for genome engineering is hampered by the fact that only a subset of sequences can be efficiently recognized using published finger archives. We describe a set of validated two-finger modules that complement existing finger archives and expand the range of ZFN-accessible sequences threefold. Using this archive, we introduced lesions at 9 of 11 target sites in the zebrafish genome.
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基因功能
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原始数据
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文献解读
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