A common genetic variant of FCN3/CD164L2 is associated with essential hypertension in a Chinese population.

Ficolin-3, encoded by FCN3, is the predominant recognition molecule of lectin pathway for the activation of complement component 3 (C3), which is an important risk factor for the development of hypertension. In our previous study, we found the complement system including ficolin-3 was overrepresented in the serum of type 2 diabetic patients. Since type 2 diabetes shares some pathogenic components, including excessive serum C3, with hypertension, this study aims to test the hypothesis that common variants at FCN3 might be associated with essential hypertension in our Chinese population. A total of 1797 subjects were recruited. Of them, 573 were with essential hypertension. Based on HapMap data, three tagging single nucleotide polymorphisms (rs2504778, rs10794501, and rs3813800) in FCN3/CD164L2 region were selected for genotyping by using MassARRAY. Logistic regression analysis was performed to evaluate the genetic effects on the prevalence of hypertension after adjusting for covariates. rs2504778, which locates in the upstream of FCN3 and in the intron of CD164L2, was found to be significantly associated with hypertension after adjusting for covariates (OR = 1.28, 95% CI: 1.05, 1.55, P = .015). Correction for multiple testing did not remarkably attenuate the significance (empirical P = .042 with 10 000 permutations). rs2504778 also showed a nominal association with systolic blood pressure (P = .044) in the quantitative trait analysis. No evidence of correlation with hypertension and blood pressure was observed for rs10794501 and rs3813800. We found that a common variant of FCN3/CD164L2 is associated with hypertension in our Chinese population. More studies with larger sample size are needed to confirm this finding.

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