The STF2p hydrophilin from Saccharomyces cerevisiae is required for dehydration stress tolerance.
PLoS ONE. 2012;7(3):e33324. Epub 2012 Mar 16
Gema López-Martínez 1
,
Boris Rodríguez-Porrata
,
Mar Margalef-Català
,
Ricardo Cordero-Otero
Gema López-Martínez 1
,
Boris Rodríguez-Porrata
,
Mar Margalef-Català
,
Ricardo Cordero-Otero
摘要
The yeast Saccharomyces cerevisiae is able to overcome cell dehydration; cell metabolic activity is arrested during this period but restarts after rehydration. The yeast genes encoding hydrophilin proteins were characterised to determine their roles in the dehydration-resistant phenotype, and STF2p was found to be a hydrophilin that is essential for survival after the desiccation-rehydration process. Deletion of STF2 promotes the production of reactive oxygen species and apoptotic cell death during stress conditions, whereas the overexpression of STF2, whose gene product localises to the cytoplasm, results in a reduction in production upon oxidative stress as the result of the antioxidant capacity of the STF2p protein.
