A natural antisense transcript regulates mucD gene expression and biofilm biosynthesis in Pseudomonas aeruginosa.
[No authors listed]
摘要
Natural antisense transcripts (NATs) are naturally widespread and have very important functions in regulating expression of their target genes. In this report, we identified a novel NAT, designated mucD-AS, transcribed from the opposite strand ofmucD gene locus, which has a pivotal function in regulating the biosynthesis of alginate. For the biotechnological and medical significance in the study of alginate biosynthesis, we investigated the effect ofmucD-AS on mucD expression and alginate biosynthesis, and confirmed mucD-AS can induce biofilm formation ofP. aeruginosa significantly. Since alginate has a key function in the infection process and acts as virulence factor of P. aeruginosa, we speculate mucD-AS may have a regulatory function in this process.
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基因功能
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原始数据
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文献解读
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