The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin.

Nat. Struct. Mol. Biol.2012 Mar 04;19(4):458-60

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摘要

SUMOylation promotes targeting of HP1Î± to pericentric heterochromatin. Here we identify the SUMO-specific protease SENP7 in mouse as a maintenance factor for HP1Î± accumulation at this location. SENP7 interacts directly with HP1Î±, localizes at HP1-enriched pericentric domains and can deconjugate SUMOylated HP1Î± in vivo. Depletion of SENP7 delocalizes HP1Î± from pericentric heterochromatin without affecting H3K9me3 levels. We propose that following targeting of HP1Î±, a subsequent deSUMOylation event enables HP1Î± retention at these domains.

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The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin.

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