Type I interferon pathway in adult and juvenile dermatomyositis.
Arthritis Res. Ther.2011;13(6):249. Epub 2011 Dec 22
Emily C Baechler 1
,
Hatice Bilgic
,
Ann M Reed
Emily C Baechler 1
,
Hatice Bilgic
,
Ann M Reed
摘要
Gene expression profiling and protein studies of the type I interferon pathway have revealed important insights into the disease process in adult and juvenile dermatomyositis. The most prominent and consistent feature has been a characteristic whole blood gene signature indicating upregulation of the type I interferon pathway. Upregulation of the type I interferon protein signature has added additional markers of disease activity and insight into the pathogenesis of the disease.
