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Type I interferon pathway in adult and juvenile dermatomyositis.

Arthritis Res. Ther.2011;13(6):249. Epub 2011 Dec 22
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摘要


Gene expression profiling and protein studies of the type I interferon pathway have revealed important insights into the disease process in adult and juvenile dermatomyositis. The most prominent and consistent feature has been a characteristic whole blood gene signature indicating upregulation of the type I interferon pathway. Upregulation of the type I interferon protein signature has added additional markers of disease activity and insight into the pathogenesis of the disease.

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