[Functioning of macromolecular complexes at successive stages of gene expression as self-coordinated molecular machines].

The results of systemic investigations devoted to the role of the proteins SAYP and ENY2 from Drosophila melanogaster in the regulation of different stages of gene expression are presented. The gene expression is a system of multistage processes involving the preparation of the chromatin matrix, initiation of transcription, mRNA synthesis, as well as the formation of mPNR particles, their export, and translation in the cytoplasm. At each of these stages, a great number of factors present6ed usually by protein complexes consisting of different subunits work. An analysis of the available evidence indicated that the transcription coactivators SAYP and ENY2 act in gene expression as cooperative nanoregulators, thereby determining the molecular mechanisms of coordination of spatial and temporal characteristics of the processes involved in the realization of genetic information.

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