Role of the recently identified dysadherin in E-cadherin adhesion molecule downregulation in head and neck cancer.

Med. Oncol.2012 Sep;29(3):1463-7. doi:10.1007/s12032-011-0118-3. Epub 2011 Nov 22

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Dysadherin is a cancer-related cell membrane glycoprotein, recently identified, playing an important role in tumor progression and metastasis. In the present minireview article, we are focusing on the role of dysadherin in E-cadherin downregulation, the various expression patterns of the molecule in head and neck cancer as well as its potential role as a molecular target for future applications in diagnosis, clinical routine and prognosis of the disease.

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Role of the recently identified dysadherin in E-cadherin adhesion molecule downregulation in head and neck cancer.

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