Click synthesis of ubiquitin dimer analogs to interrogate linkage-specific UBA domain binding.
Chem. Commun. (Camb.). 2012 Jan 7;48(2):296-8. doi:10.1039/c1cc15834a. Epub 2011 Nov 18
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摘要
A new route to the synthesis of triazole-linked ubiquitin dimers (diUbs) as structural analogs of the seven diUbs is reported. Binding studies with the Lys48-specific UBA domain of the Mud1 protein suggest that they represent functionally suitable surrogates of their native counterparts linked by an isopeptide bond.
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基因功能
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原始数据
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文献解读
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