Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway.

Nat. Struct. Mol. Biol.2011 Nov 13;18(12):1432-4

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Metabolism is predicted to generate formaldehyde, a toxic, simple, reactive aldehyde that can damage DNA. Here we report a synthetic lethal interaction in avian cells between ADH5, encoding the main formaldehyde-detoxifying enzyme, and the Fanconi anemia (FA) DNA-repair pathway. These results define a fundamental role for the combined action of formaldehyde catabolism and DNA cross-link repair in vertebrate cell survival.

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Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway.

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