High-dose siRNAs upregulate mouse Eri-1 at both transcription and posttranscription levels.
PLoS ONE. 2011;6(10):e26466. Epub 2011 Oct 19
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摘要
The eri-1 gene encodes a 3' exonuclease that can negatively regulate RNA interference via siRNase activity. High-dose siRNAs (hd-siRNAs) can enhance Eri-1 expression, which in return degrade siRNAs and greatly reduces efficiency. Here we report that hd-siRNAs induce mouse Eri-1 (meri-1) expression through the recruitment of Sp1, Ets-1, and to the meri-1 promoter and the formation of an complex. In addition, hd-siRNAs also abolish the 3' untranslated region (UTR) mediated posttranscriptional repression of meri-1. Our findings demonstrate the molecular mechanism underlying the upregulation of meri-1 by hd-siRNA.
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基因功能
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原始数据
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文献解读
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