A mutation of ispA that is involved in isoprenoid biogenesis can improve growth of Escherichia coli at low temperatures.

Microbiol. Immunol.2011 Dec;55(12):885-8. doi:10.1111/j.1348-0421.2011.00391.x

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Cells lacking rodZ are defective not only in cell shape, but also in cell growth at low temperatures. Cold-sensitive growth was suppressed by a mutation of ispA without recovery from the round shape, and the mutation improved cell growth of the wild-type at low temperatures.

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A mutation of ispA that is involved in isoprenoid biogenesis can improve growth of Escherichia coli at low temperatures.

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