A yeast two hybrid screen identifies SPATA4 as a TRAPP interactor.
[No authors listed]
摘要
The TRAPP vesicle-tethering complex consists of more than 10 distinct polypeptides and is involved in protein transport. Using the C2 subunit as bait we identified a spermatocyte-specific protein of unknown function, as an interacting partner in a yeast two hybrid screen. Further studies indicate interacts with the C2 portion of the TRAPP complex. duanyu1842TA4 fractionates with both cytosolic and nuclear fractions suggesting it may have several distinct functions. duanyu1842TA4 is one of only three human proteins that contain a DUF1042 domain and we show that C2 does not interact with another one of the DUF1042 domain-containing proteins. Our results suggest a role for duanyu1842TA4 in membrane traffic and a specialized function for TRAPP in spermatocytes.
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基因功能
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原始数据
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文献解读
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