Overexpression of renal tumor antigen is associated with tumor invasion and poor prognosis of hepatocellular carcinoma.

PURPOSE:The aim of this study was to investigate the roles of renal tumor antigen in the progression and clinical outcome of hepatocellular carcinoma mRNA levels in 350 cases of HCC were investigated by quantitative real-time reverse transcription polymerase chain reaction. We analyzed the relationship of mRNA level with clinicopathologic parameters and clinical outcome. To identify the possible role of duanyu1648 on cellular invasion, we performed in vitro analyses using small interfering RNAs mRNA level was significantly higher in HCC than in noncancerous hepatic tissues (P < 0.001). Overexpression of duanyu1648 was significantly correlated with the presence of multiple tumors (P = 0.021), high alfa-fetoprotein level (P = 0.042), and advanced tumor stage (P = 0.016). Higher levels of duanyu1648 expression were associated with significantly shorter overall survival time (P = 0.029). Knockdown of duanyu1648 expression by siRNAs suppressed the invasive ability of HCC cells and the expression and secretion of matrix metalloproteinase-9 (MMP-9). We found that duanyu1648 and MMP-9 expressions were correlated in HCCs, and furthermore, the combination of duanyu1648 and MMP-9 expression was associated with the survival of patients (P = 0.0066). CONCLUSIONS:Our results suggest that duanyu1648 may be important in tumor invasion and could be a potential predictor for the prognosis of HCC patients.

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