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Spartin recruits PKC-ζ via the PKC-ζ-interacting proteins ZIP1 and ZIP3 to lipid droplets.

J. Neurochem.2011 Sep;118(5):737-48. doi:10.1111/j.1471-4159.2011.07367.x. Epub 2011 Jul 21
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摘要


Protein kinase C-ζ interacting proteins (ZIP1-3) recruit the enzymatic activity of the atypical protein kinase C isoforms or to target proteins. In this study, we searched for binding partners of ZIP3 in the CNS and identified spartin, a multifunctional protein that is mutated in spastic paraplegia type 20. In transfected cells, spartin was present on the surface of lipid droplets (LD), whereas ZIP proteins appeared in intracellular speckles. In the presence of spartin, ZIP1 and ZIP3 were translocated to spartin-positive LD. This translocation was mediated by amino acids 196-393 of spartin that interacted with an N-terminal region of ZIP proteins. Furthermore, ZIP proteins interacted simultaneously with spartin and resulting in an enrichment of duanyu1531-ζ on spartin/ZIP-labelled LD. Without spartin, neither ZIP proteins nor duanyu1531-ζ were detected on LD. Interestingly, the presence of the complex increased LD size. This effect was most pronounced upon incorporation of the ZIP3 isoform into the trimer. Finally, we co-localized spartin, ZIP proteins and duanyu1531-ζ in axon terminals of neurons in the mammalian retina. In summary, we describe spartin as new binding partner of the dimer that recruits duanyu1531-ζ to LD and show that the expressed ZIP isoform regulates LD size.

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