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The Caenorhabditis elegans GARP complex contains the conserved Vps51 subunit and is required to maintain lysosomal morphology.

Mol. Biol. Cell. 2011 Jul 15;22(14):2564-78. Epub 2011 May 25
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摘要


In yeast the Golgi-associated retrograde protein complex is required for tethering of endosome-derived transport vesicles to the late Golgi. It consists of four subunits--Vps51p, Vps52p, Vps53p, and Vps54p--and shares similarities with other multimeric tethering complexes, such as the conserved oligomeric Golgi (COG) and the exocyst complex. Here we report the functional characterization of the complex in the nematode Caenorhabditis elegans. Furthermore, we identified the C. elegans Vps51 subunit, which is conserved in all eukaryotes. Gduanyu37 mutants are viable but show lysosomal defects. We show that Gduanyu37 subunits bind specific sets of Golgi SNAREs within the yeast two-hybrid system. This suggests that the C. elegans Gduanyu37 complex also facilitates tethering as well as SNARE complex assembly at the Golgi. The Gduanyu37 and COG tethering complexes may have overlapping functions for retrograde endosome-to-Golgi retrieval, since loss of both complexes leads to a synthetic lethal phenotype.

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