Characterization of peptide chain length and constituency requirements for YejABEF-mediated uptake of microcin C analogues.
J. Bacteriol.2011 Jul;193(14):3618-23. Epub 2011 May 20
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摘要
Microcin C (McC), a natural antibacterial compound consisting of a heptapeptide attached to a modified adenosine, is actively taken up by the YejABEF transporter, after which it is processed by cellular aminopeptidases, releasing the nonhydrolyzable aminoacyl adenylate, an inhibitor of aspartyl-tRNA synthetase. McC analogues with variable length of the peptide moiety were synthesized and evaluated in order to characterize the substrate preferences of the YejABEF transporter. It was shown that a minimal peptide chain length of 6 amino acids and the presence of an N-terminal formyl-methionyl-arginyl sequence are required for transport.
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基因功能
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原始数据
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文献解读
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