Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest.

J Assist Reprod Genet. 2011 Aug;28(8):743-6. doi:10.1007/s10815-011-9576-y. Epub 2011 May 04

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PURPOSE:To investigate the association between the UBR2 gene and the risk of azoospermia caused by meiotic arrest. METHODS:Mutational analysis of the UBR2 gene was performed using DNA from 30 patients with azoospermia by meiotic arrest to 80 normal controls. RESULTS:The genotypic and allelic frequencies of c.1,066A>T variant were significantly higher in patient than control groups (pâ<â0.001). CONCLUSION:The c.1,066A>T variant in the UBR2 gene is associated with increased susceptibility to azoospermia caused by meiotic arrest.

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Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest.

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