FoxO regulates expression of decidual protein induced by progesterone (DEPP) in human endothelial cells.

FEBS Lett.2011 Jun 23;585(12):1796-800. Epub 2011 Apr 15

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DEPP was initially cloned from the human endometrial stromal cell cDNA library, but the transcriptional regulation of DEPP remains largely unknown. We demonstrate here that expression of DEPP is FoxO-dependent in human endothelial cells. Two functional FoxO-responsive elements are identified in the DEPP promoter. Hypoxia stimulates DEPP expression in the endothelial cell line EA.hy926. Hypoxia-induced upregulation of DEPP is dependent on FoxO expression. We conclude that DEPP is regulated at the level of transcription by FoxO in human vascular endothelial cells.

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FoxO regulates expression of decidual protein induced by progesterone (DEPP) in human endothelial cells.

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