Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
PLoS Genet.2011 Apr;7(4):e1002033. doi:10.1371/journal.pgen.1002033. Epub 2011 Apr 07
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摘要
We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4 Ã 10(-19)), near AHR, and 15q24 (P = 5.2 Ã 10(-14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2.
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基因功能
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原始数据
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文献解读
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