[Expression and clinical significance of human nuclear distribution C in nasopharyngeal carcinoma].

OBJECTIVE:To investigate the expression and clinical significance of human nuclear distribution (hNudC) in nasopharyngeal carcinoma (NPC). METHOD:Immunohistochemical and western blot method were used to determine the expression of human nuclear distribution C in 80 cases of NPC and 30 cases of chronic inflammation of nasopharyngeal mucosa. The amounts of positive cells were analyzed . The relationship between the gene expression and clinic pathological features was analyzed too. RESULT:The positive expression rate of human nuclear distribution C in NPC was 83.75%, which was higher than that in chronic inflammation of nasopharyngeal mucosa 23.33% (P < 0.05). The expression of human nuclear distribution C was positively correlated with the clinic pathological stages in NPC (P < 0.05), and positive expression rate of hNudC protein was increased with the progress of NPC clinical stage (P < 0.05). CONCLUSION:Human nuclear distribution C is found to be closely associated with cell malignant hyperplasia. This protein is important indicators to predict the progression of patients.

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