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Exploring the evolutionary relationship of insulin receptor substrate family using computational biology.

PLoS ONE. 2011 Feb 25;6(2):e16580. doi:10.1371/journal.pone.0016580
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摘要

Insulin receptor substrate (IRS) harbors proteins such as IRS1, IRS2, IRS3, IRS4, IRS5 and IRS6. These key proteins act as vital downstream regulators in the insulin signaling pathway. However, little is known about the evolutionary relationship among the IRS family members. This study explores the potential to depict the evolutionary relationship among the IRS family using bioinformatics, algorithm analysis and mathematical models.

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