Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion.
Biochem. Biophys. Res. Commun.2011 Jan 7;404(1):103-8. Epub 2010 Nov 21
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摘要
Clec14a is a member of the thrombomodulin (TM) family, but its function has not yet been determined. Here, we report that Clec14a is a plasma membrane protein of endothelial cells (ECs) expressed specifically in the vasculature of mice. Deletion mutant analysis revealed that Clec14a mediates cell-cell adhesion through its C-type lectin-like domain. Knockdown of Clec14a in ECs suppressed cell migratory activity and filopodial protrusion, and delayed formation of tube-like structures. These findings demonstrate that Clec14a is a novel EC-specific protein that appears to play a role in cell-cell adhesion and angiogenesis.
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基因功能
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原始数据
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文献解读
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