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Structure of Plasmodium falciparum ADP-ribosylation factor 1.

Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.2010 Nov 01;66(Pt 11):1426-31. Epub 2010 Oct 27
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摘要


Vesicular trafficking may play a crucial role in the pathogenesis and survival of the malaria parasite. ADP-ribosylation factors (ARFs) are among the major components of vesicular trafficking pathways in eukaryotes. The crystal structure of ARF1 GTPase from Plasmodium falciparum has been determined in the GDP-bound conformation at 2.5 Å resolution and is compared with the structures of mammalian ARF1s.

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