TRIM39 and RNF39 are associated with BehÃ§et's disease independently of HLA-Bâ51 and -Aâ26.

Biochem. Biophys. Res. Commun.2010 Oct 29;401(4):533-7. Epub 2010 Sep 27

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摘要

Behcet's disease (BD) is a chronic inflammatory autoimmune disease and strongly associated with human leukocyte antigen (HLA)-Bâ51 and -Aâ26. We examined whether other genetic factors may exist in HLA region by 135 single nucleotide polymorphisms (SNPs) in 384 pairs of Japanese BD patients and controls. Multiple logistic regression analysis identified two novel susceptibility SNPs: rs9261365 near a ring finger protein (RNF) 39 and rs2074474 on exon 9 of tripartite motif-containing (TRIM) 39 independently of HLA-Bâ51 and -Aâ26 alleles. Our findings suggest that RNF39 and TRIM39 are involved in the etiology of BD.

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TRIM39 and RNF39 are associated with BehÃ§et's disease independently of HLA-Bâ51 and -Aâ26.

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TRIM39 and RNF39 are associated with BehÃ§et's disease independently of HLA-Bâ51 and -Aâ26.

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TRIM39 and RNF39 are associated with BehÃ§et's disease independently of HLA-Bâ51 and -Aâ26.