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[Association between polymorphism in DVWA and IL-1beta and Kashin-Beck disease].

Sichuan Da Xue Xue Bao Yi Xue Ban. 2010 Jul;41(4):669-73
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摘要

OBJECTIVE:To investigate the association between IL-1beta and DVWA gene and Kashin-Beck disease (KBD). METHODS:Peripheral genomic DNA were extracted from 105 patients with KBD and 98 healthy controls. PCR-RFLP were performed to detect SNP loci of IL-1beta gene and DVWA gene. RESULTS:The patients with KBD had significantly higher frequency of rs16944 (IL-1beta) locus (chi2 = 24.28, P < 0.001) and single allele frequency of rs16944 (chi2 = 5.683, P = 0.0171) than the healthy controls. There were no significant differences in genotype frequencies,single allele frequencies and haplotypes in rs4685241 and rs1143627 between the patients with KBD and the healthy controls. CONCLUSION:rs16944 (IL-1beta) is associated with KBD.

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