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Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.

Nat Genet. 2010 Sep;42(9):739-741. doi:10.1038/ng.639. Epub 2010 Aug 08
Thorsten Thye 1 , Fredrik O Vannberg 2 , Sunny H Wong 2 , Ellis Owusu-Dabo 3 , Ivy Osei 4 , John Gyapong 4 , Giorgio Sirugo 5 , Fatou Sisay-Joof 5 , Anthony Enimil 6 , Margaret A Chinbuah 4 , Sian Floyd 7 , David K Warndorff 8 , Lifted Sichali 8 , Simon Malema 8 , Amelia C Crampin 7 , Bagrey Ngwira 8 , Yik Y Teo 2 , Kerrin Small 2 , Kirk Rockett 2 , Dominic Kwiatkowski 2 , Paul E Fine 8 , Philip C Hill 5 , Melanie Newport 5 , Christian Lienhardt 5 , Richard A Adegbola 5 , Tumani Corrah 5 , Andreas Ziegler 1 , African TB Genetics Consortium , Wellcome Trust Case Control Consortium , Andrew P Morris 2 , Christian G Meyer 9 , Rolf D Horstmann 9 , Adrian V S Hill 2
Thorsten Thye 1 , Fredrik O Vannberg 2 , Sunny H Wong 2 , Ellis Owusu-Dabo 3 , Ivy Osei 4 , John Gyapong 4 , Giorgio Sirugo 5 , Fatou Sisay-Joof 5 , Anthony Enimil 6 , Margaret A Chinbuah 4 , Sian Floyd 7 , David K Warndorff 8 , Lifted Sichali 8 , Simon Malema 8 , Amelia C Crampin 7 , Bagrey Ngwira 8 , Yik Y Teo 2 , Kerrin Small 2 , Kirk Rockett 2 , Dominic Kwiatkowski 2 , Paul E Fine 8 , Philip C Hill 5 , Melanie Newport 5 , Christian Lienhardt 5 , Richard A Adegbola 5 , Tumani Corrah 5 , Andreas Ziegler 1 , African TB Genetics Consortium , Wellcome Trust Case Control Consortium , Andrew P Morris 2 , Christian G Meyer 9 , Rolf D Horstmann 9 , Adrian V S Hill 2
+ et al

[No authors listed]

Author information
  • 1 Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
  • 2 Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
  • 3 Department of Community Health, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
  • 4 Health Research Unit, Ghana Health Service, Accra, Ghana.
  • 5 MRC Laboratories, Fajara, Banjul, The Gambia.
  • 6 Komfo Anokye Teaching Hospital, Kumasi, Ghana.
  • 7 London School of Hygiene and Tropical Medicine, London, United Kingdom.
  • 8 Karonga Prevention Study, Chilumba, Karonga District, Malawi.
  • 9 Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.

摘要

We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.

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