Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy.
Nat. Neurosci.2010 Sep;13(9):1056-8. Epub 2010 Aug 01
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摘要
We found the voltage-gated K+ channel Kv12.2 to be a potent regulator of excitability in hippocampal pyramidal neurons. Genetic deletion and pharmacologic block of Kv12.2 substantially reduced the firing threshold of these neurons. Kv12.2-/- (also known as Kcnh3-/-) mice showed signs of persistent neuronal hyperexcitability including frequent interictal spiking, spontaneous seizures and increased sensitivity to the chemoconvulsant pentylenetetrazol.
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文献解读
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