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Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.

Nat Genet. 2010 Jul;42(7):608-13. Epub 2010 Jun 06
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摘要


Platelet function mediates both beneficial and harmful effects on human health, but few genes are known to contribute to variability in this process. We tested association of 2.5 million SNPs with platelet aggregation responses to three agonists (ADP, epinephrine and collagen) in two cohorts of European ancestry (N

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