PIASy interacts with p73alpha and regulates cell cycle in HEK293 cells.
[No authors listed]
摘要
p73, a recently described member of the p53 family of transcription factors, undergoes a number of posttranslational modifications, inducing cell cycle arrest and apoptosis. In the present study, we demonstrate that PIASy, a member of the PIAS SUMO-ligase family, interacts with p73alpha, and that PIASy-mediated sumoylation promotes proteasomal degradation of p73alpha. PIASy overexpression inhibits p73alpha-mediated transcription of p21, with a reduction of cells in G1 and cell cycle reentry. These results suggest that PIASy plays an important role in regulation of p73alpha transcriptional activity and is also a regulator of the cell cycle machinery.
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基因功能
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原始数据
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文献解读
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