Proteome analysis of lumbar spinal cord from rats submitted to peripheral lesion during neonatal period.

J Neural Transm (Vienna). 2010 Jun;117(6):689-93. doi:10.1007/s00702-010-0403-x. Epub 2010 Apr 13

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Every year traumatic peripheral nerve injuries (TPNI) result in considerable physical disability across the world; the mechanisms of plasticity and reorganization of spinal cord circuits following such injuries are complex and not completely understood. A comparative proteome analysis between neonatal rats submitted to peripheral lesion and controls was performed; a number of differentially expressed proteins involved in oxidative stress response, energy metabolism and cytoskeleton rearrangement were revealed, which may support future studies to help in the understanding and a posteriori the treatment of TPNI.

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Proteome analysis of lumbar spinal cord from rats submitted to peripheral lesion during neonatal period.

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