TARPs differentially decorate AMPA receptors to specify neuropharmacology.

Transmembrane AMPA receptor regulatory proteins are the first identified auxiliary subunits for a neurotransmitter-gated ion channel. Although initial studies found that stargazin, the prototypical principally chaperones AMPA receptors, subsequent research demonstrated that it also regulates AMPA receptor kinetics and synaptic waveforms. Recent studies have identified a diverse collection of isoforms--types Ia, Ib II--that distinctly regulate AMPA receptor trafficking, gating and neuropharmacology. These Tduanyu37 isoforms are heterogeneously expressed in specific neuronal populations and can differentially sculpt synaptic transmission and plasticity. Whole-genome analyses also link multiple Tduanyu37 loci to childhood epilepsy, schizophrenia and bipolar disorder. emerge as vital components of excitatory synapses that participate both in signal transduction and in neuropsychiatric disorders.

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