Inflammasome activation: how macrophages watch what they eat.

Cell Host Microbe. 2010 Jan 21;7(1):3-5

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Underhill and colleagues (Shimada et al., 2010) provide evidence for an intriguing link between the activity of lysozyme in the phagosome and activation of the Nlrp3 inflammasome, a cytosolic regulator of inflammation and cytokine production. The authors show that resistance to lysozyme allows Staphylococcus aureus to evade Nlrp3 activation.

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Inflammasome activation: how macrophages watch what they eat.

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