Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation.

Nat Struct Mol Biol. 2010 Feb;17(2):238-40. Epub 2010 Jan 24

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摘要

GW182-family proteins are essential for microRNA-mediated translational repression and deadenylation in animal cells. Here we show that a conserved motif in the human GW182 paralog TNRC6C interacts with the C-terminal domain of polyadenylate binding protein 1 (PABC) and present the crystal structure of the complex. Mutations at the complex interface impair mRNA deadenylation in mammalian cell extracts, suggesting that the GW182-PABC interaction contributes to microRNA-mediated gene silencing.

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Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation.

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