[Polymorphism of ARLTS1 gene in early-onset ovarian cancer].

OBJECTIVE:To evaluate the impact of ARLTS1 gene mutations among Chinese Han-nationality patients with early-onset epithelial ovarian carcinoma (OC) in Southern China. METHODS:Tumor and blood samples collected from early-onset, late-onset epithelial ovarian carcinoma patients and control group were collected. After purification of DNA, the ARLTS1 gene fragments were amplified with PCR. The DHPLC was applied to analyze the PCR products. The mutation products were confirmed with DNA sequencing analysis. RESULTS:ARLTS1 Cys148Arg revealed a significant association with an increased risk in early-onset OC group compared with both late-onset cases and controls. ARLTS1 Ser99Ser revealed no impact on both early-onset OC group and late-onset cases. CONCLUSION:A significantly increased risk for young ovarian cancer patients with ARLTS1 Cys148Arg variant were observed, which indicate that ARLTS1 may play a important role in early-onset of OC.

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