cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily.

Biochim. Biophys. Acta. 1991 Feb 16;1088(2):319-22

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摘要

A 1.96 kbp cDNA encoding a male Beagle dog liver cytochrome P-450 of 503 amino acid residues (Mr 57,636) has been isolated and sequenced. The deduced amino acid sequence is 79.8%, 69.3% and 74.1% identical to the P450IIIA forms human NF25, rat PCN1 and rabbit LM3c, respectively. The amino terminal sequence is identical to the first 28 residues of the dog P450IIIA form PBD-1. Southern blot analysis yields restriction patterns consistent with IIIA gene subfamily multiplicity.

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cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily.

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