Ureide catabolism in Arabidopsis thaliana and Escherichia coli.
Nat Chem Biol. 2010 Jan;6(1):19-21. Epub 2009 Nov 22
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摘要
The availability of whole genome sequences boosts the identification of biochemical pathways conserved across species using tools of comparative genomics. A cross-organism protein association analysis allowed us to identify two enzymes, ureidoglycine aminohydrolase and ureidoglycolate amidohydrolase, that catalyze the final reactions of purine degradation in the model plant Arabidopsis thaliana. A similar pathway was found in Escherichia coli, while an alternative metabolic route via ureidoglycine transaminase can be predicted for other organisms.
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基因功能
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原始数据
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文献解读
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