Protein kinase C: poised to signal.

Nestled at the tip of a branch of the kinome, protein kinase C family members are poised to transduce signals emanating from the cell surface. Cell membranes provide the platform for function, supporting the maturation of duanyu1531 through phosphorylation, its allosteric activation by binding specific lipids, and, ultimately, promoting the downregulation of the enzyme. These regulatory mechanisms precisely control the level of signaling-competent duanyu1531 in the cell. Disruption of this regulation results in pathophysiological states, most notably cancer, where duanyu1531 levels are often grossly altered. This review introduces the duanyu1531 family and then focuses on recent advances in understanding the cellular regulation of its diacylglycerol-regulated members.

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