[No authors listed]
The MgtA protein from Salmonella enterica serovar Typhimurium mediates Mg(2+) uptake from the periplasm into the cytoplasm. Here we report that the PhoP/PhoQ two-component regulatory system, which responds to periplasmic Mg(2+), governs mgtA transcription initiation at all investigated Mg(2+) concentrations and that the Mg(2+)-sensing 5' leader region of the mgtA gene controls transcription elongation into the mgtA coding region when Salmonella is grown in media with <50 muM Mg(2+). Overexpression of the Mg(2+) transporter CorA, which is believed to increase cytoplasmic Mg(2+) levels, decreased mgtA transcription in a manner dependent on a functional mgtA 5' leader.
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