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Synthesis of a tetrasaccharide related to the repeating unit of the O-antigen from Escherichia coli K-12.

Carbohydr Res. 2009 Nov 23;344(17):2311-6. Epub 2009 Sep 25
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摘要


Synthesis of a tetrasaccharide related to the repeating unit of the O-antigen from Escherichia coli K-12 is reported in the form of its octyl glycoside. Syntheses of the 1,2-cis glycosidic linkages have been accomplished by using NIS in conjunction with H(2)SO(4)-silica, and it was found to be stereoselective and productive. The synthesized tetrasaccharide will be utilized as the substrate for galactofuranosyltransferase, WbbI.

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