ScoC regulates bacilysin production at the transcription level in Bacillus subtilis.
J. Bacteriol.2009 Dec;191(23):7367-71. Epub 2009 Oct 02
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摘要
Bacillus subtilis mutants with high expression of the bacilysin operon ywfBCDEFG were isolated. Comparative genome sequencing analysis revealed that all of these mutants have a mutation in the scoC gene. The disruption of scoC by genetic engineering also resulted in increased expression of ywfBCDEFG. Primer extension and gel mobility shift analyses showed that the ScoC protein binds directly to the promoter region of ywfBCDEFG. Our results indicate that the transition state regulator ScoC, together with CodY and AbrB, negatively regulates bacilysin production in B. subtilis.
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基因功能
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原始数据
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文献解读
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