Regulating the regulator: an RNA decoy acts as an OFF switch for the regulation of an sRNA.
Genes Dev. 2009 Sep 01;23(17):1981-5
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摘要
Many bacterial small regulatory RNAs (sRNAs) pair with mRNA targets, stimulating or inhibiting mRNA stability and/or translation. Regulation of these sRNAs is usually due to tight transcriptional regulation of synthesis.In this issue of Genes & Development and a related paper in Molecular Microbiology, Figueroa-Bossi and colleagues (pp. 2004-2015) and Overgaard and colleagues report a novel regulatory mechanism in which induction of a competing mRNA acts to titrate away the sRNA, allowing expression of an otherwise strongly inhibited target gene.
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基因功能
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原始数据
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文献解读
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