Biochemical characterisation of the SWI/SNF family member HLTF.
Biochem Biophys Res Commun. 2009 Dec 11;390(2):187-91. Epub 2009 Aug 31
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摘要
HLTF is highly similar in domain organisation to yeast Rad5. We identify PTIP and RPA70, both involved in DNA replication and DNA repair, as HLTF-interacting proteins although cells depleted of HLTF did not show defects in cellular responses to DNA damage. In vitro, HLTF has ATPase activity and E3 ubiquitin ligase activity with a range of E2 ubiquitin conjugating enzymes. HLTF expression is severely reduced in a range of cancer cells, and we suggest that the HLTF antibodies generated in this study could be used for cancer diagnostic purposes.
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基因功能
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原始数据
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文献解读
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