Agouti C57BL/6N embryonic stem cells for mouse genetic resources.
Nat Methods. 2009 Jul;6(7):493-5. Epub 2009 Jun 14
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摘要
We report the characterization of a highly germline competent C57BL/6N mouse embryonic stem cell line, JM8. To simplify breeding schemes, the dominant agouti coat color gene was restored in JM8 cells by targeted repair of the C57BL/6 nonagouti mutation. These cells provide a robust foundation for large-scale mouse knockout programs that aim to provide a public resource of targeted mutations in the C57BL/6 genetic background.
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基因功能
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原始数据
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文献解读
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