Hydroxyl radicals are involved in cell killing by the bacterial topoisomerase I cleavage complex.

J Bacteriol. 2009 Aug;191(16):5315-9. Epub 2009 Jun 12

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Escherichia coli expressing SOS-inducing mutant topoisomerase I was utilized to demonstrate that covalent protein-DNA complex accumulation results in oxidative damage. Hydroxyl radicals were detected following mutant topoisomerase induction. The presence of the Fe(2+) chelator 2,2'-dipyridyl and an iscS mutation affecting Fe-S cluster formation protect against topoisomerase I cleavage complex-mediated cell killing.

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Hydroxyl radicals are involved in cell killing by the bacterial topoisomerase I cleavage complex.

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