Molecular properties, functions, and potential applications of NAD kinases.

Acta Biochim. Biophys. Sin. (Shanghai). 2009 May;41(5):352-61. doi:10.1093/abbs/gmp029

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摘要

NAD kinase catalyzes the phosphorylation of NAD(H) to form NADP(H), using ATP as phosphoryl donor. It is the only key enzyme leading to the de novo NADP(+)/NADPH biosynthesis. Coenzymes such as NAD(H) and NADP(H) are known for their important functions. Recent studies have partially demonstrated that NAD kinase plays a crucial role in the regulation of NAD(H)/NADP(H) conversion. Here, the molecular properties, physiologic functions, and potential applications of NAD kinase are discussed.

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Molecular properties, functions, and potential applications of NAD kinases.

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