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Structure of pig heart citrate synthase at 1.78 A resolution.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 May 01;65(Pt 5):430-4. Epub 2009 Apr 24
Steven B Larson 1 , John S Day , Chieugiang Nguyen , Robert Cudney , Alexander McPherson
Steven B Larson 1 , John S Day , Chieugiang Nguyen , Robert Cudney , Alexander McPherson

[No authors listed]

Author information
  • 1 Department of Molecular Biology and Biochemistry, The University of California, Irvine, 92697-3900, USA.

摘要


Pig heart citrate synthase was crystallized from a small-molecule cocktail containing cystamine dihydrochloride, aspartame and benzamidine hydrochloride. The structure was refined to an R factor of 0.179 (R(free) = 0.222) using synchrotron data to a resolution of 1.78 A. The model includes the full-length protein, a chloride ion, a sulfate ion, 305 water molecules and an unexpected moiety attached through a disulfide linkage to Cys184, which was modeled as a half-cystamine molecule generated by disulfide exchange with the cystamine in the small-molecule cocktail.