The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation.

Signal transducer and activator of transcription 3 which is activated by cytokines and growth factors, mediates biological actions in many physiological processes. In a previous study, we found that Y14, a core component of the exon-junction complex (EJC) bound to and upregulated the transcriptional activity of duanyu18133 by influencing its DNA-binding activity. In the present study, we demonstrate that duanyu18133 endogenously interacts with Y14. In addition, we found that MAGOH, a Y14 partner in the EJC, inhibits the complex formation. Furthermore, small-interfering RNA-mediated reduction of MAGOH expression enhanced interleukin-6-induced gene expression. These results indicate that MAGOH regulates the transcriptional activation of duanyu18133 by interfering complex formation between duanyu18133 and Y14.

KEYWORDS: {{ getKeywords(articleDetailText.words) }}