例如:"lncRNA", "apoptosis", "WRKY"

Signal transduction and adaptive regulation through bacterial two-component systems: the Escherichia coli AtoSC paradigm.

Amino Acids. 2009 Sep;37(3):443-58. doi:10.1007/s00726-009-0241-z. Epub 2009 Feb 08
Dimitrios A Kyriakidis 1 , Ekaterini Tiligada
Dimitrios A Kyriakidis 1 , Ekaterini Tiligada

[No authors listed]

Author information
  • 1 Department of Chemistry, Aristotle University of Thessaloniki, Greece. kyr@eie.gr

摘要


Adaptive signal transduction within microbial cells involves a multi-faceted regulated phosphotransfer mechanism that comprises structural rearrangements of sensor histidine kinases upon ligand-binding and phosphorylation-induced conformational changes in response regulators of versatile two-component systems (TCS), arisen early in bacterial evolution. In Escherichia coli, cross-talk between the AtoS histidine kinase and the AtoC response regulator, forming the AtoSC TCS, through His --> Asp phosphotransfer, activates AtoC directly to induce atoDAEB operon expression, thus modulating diverse fundamental cellular processes such as short-chain fatty acid catabolism, poly-(R)-3-hydroxybutyrate biosynthesis and chemotaxis. Among the inducers hitherto identified, acetoacetate is the classical activator. The AtoSC TCS functional modulation by polyamines, histamine and Ca(2+), as well as the role of AtoC as transcriptional regulator, add new promising perspectives in the physiological significance and potential pharmacological exploitation of this TCS in cell proliferation, bacteria-host interactions, chemotaxis, and adaptation.